A comparative analysis and assessment of TCR technologies, pipelines and companies from an industry perspective
Therapeutic monoclonal antibodies have become an increasingly successful treatment modality with sales of US$ 65 bln in the year 2012 and with an average (continuous) annual growth rate from 2006 to 2012 of 18.9%. While antibody technologies are steadily evolving, the spectrum of druggable targets for monoclonal antibodies has remained limited to extracellular antigens, albeit including proteins, carbohydrates and glycolipids.
Access to druggable, IP-protected and validated new targets is a major bottleneck in the biopharmaceutical industry. Technologies which can deliver both new targets and the corresponding treatment modality, can expect significant financial acknowledgement.
The T-cell receptor (TCR) has recently emerged as a means to target peptide antigens derived from intracellular proteins, however, in a major histocompatibility complex (MHC)-restricted manner. The first companies have overcome significant technical hurdles in putting together a library of viable new TCR-targeted antigens and establish the corresponding standardized protein- and cell-based therapeutic frameworks.
This report entitled, “The Engineered T-Cell Receptor in Fusion Proteins, Antibodies & Cells: Emerging Opportunities for the Biopharmaceutical Industry” published in Ocotber 2013 describes chances and pitfals in exploiting the opportunities which offers the engineered T-cell receptor as integral part of fusion proteins, antibodies and cellular products. The key success factors are highlighted, the technical challenges described and solutions presented.
Benefits from the report:
- Identify players in the field, from industry and academia;
- Find out which TCR technologies are valued by Big Pharma and Biotech;
- Understand the value of intracellular antigens targeted by the TCR;
- Recognize the challenges of TCR-based therapeutics and their solutions;
- Learn which TCR-based therapeutics are attractive for partnering;
- Find out which TCR therapeutic approaches are not yet tapped.
Spanning over 84 pages and 5 table, “The Engineered T-Cell Receptor in Fusion Proteins, Antibodies & Cells: Emerging Opportunities for the Biopharmaceutical Industry” report provides information on market overview, drivers and challenge, competition and key trends.
In addition to covering the The T-Cell Receptor, TCR Fusion Proteins, TCR-Like (TCRL) Antibodies, TCR-Transfected T-Cells, Artificial TCR T-Cells: Chimeric Antigen Receptor (CAR) T-Cells, Tumor-Infiltrating Lymphocytes (TILs), Opportunity Analysis for TCR-based Products and Technologies, Corporate R&D Pipelines.
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